The Thick Ortho-K Drop is generally used just before going to bed. It can be reinstilled in the middle of the night if needed.
Use the Thin Ortho-K Drops generally first thing upon opening your eyes to moisturize and loosen up the lens for removal, then as often as necessary throughout the day. In fact, you should let your symptoms be your guide. Since these drops stimulate your body’s own ability to eliminate symptoms, you should use them as soon as you notice the symptoms returning.